Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
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United States of America Patent
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Aug 26, 2003
Grant Date -
Sep 12, 2002
app pub date -
Apr 27, 2001
filing date -
Apr 28, 2000
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Abstract
Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.
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