Method of promoting chondrocyte differentiation with hedgehog related polypeptides
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United States of America Patent
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Aug 26, 2003
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N/A
app pub date -
Oct 20, 1997
filing date -
Dec 30, 1993
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Expired
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Abstract
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
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