Compositions and methods for modulating RNA

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United States of America Patent

PATENT NO 6610663
APP PUB NO 20020160972A1
SERIAL NO

09974326

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Abstract

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Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC2280 FARADAY AVENUE CARLSBAD CA 92008 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bruice, Thomas Carlsbad, CA 6 283
Cook, Phillip Dan Carlsbad, CA 180 11137
Griffey, Richard San Marcos, CA 48 2364
Guinosso, Charles John Vista, CA 10 511
Kawasaki, Andrew Mamoru Oceanside, CA 13 988

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