Method of inhibiting cell proliferation using an anti-oncogene protein
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United States of America Patent
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Sep 2, 2003
Grant Date -
Dec 19, 2002
app pub date -
Mar 19, 1998
filing date -
Mar 19, 1998
priority date (Note) -
Expired
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Abstract
The present invention provides a novel method of inhibiting the growth of tumor cells based upon the discovery that p19.sup.ARF acts as a suppressor of oncogenic transformation by binding to the MDM2 oncoprotein and blocking MDM2's ability to target associated proteins, such as p53 and Rb, for proteosomal degradation. The method provided by the present invention inhibits the growth of a tumor cell by administering to the cell an effective amount of p19.sup.ARF or a mimetic thereof, and p53 to inhibit the growth of the tumor cell. Also provided by the present invention are pharmaceutical composition comprising p19.sup.ARF or a mimetic thereof, and/or p53.
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