HSV viral vector
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United States of America Patent
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-
Sep 2, 2003
Grant Date -
Mar 7, 2002
app pub date -
Jan 28, 1997
filing date -
Jul 29, 1994
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A recombinant herpes simplex virus (HSV) viral vector genome which has substantially lost its transducing properties as a result of a DNA sequence change in the gene coding for Vmw65 protein and also contains an expressable heterologous gene inserted into a region of the HSV genome which is non-essential for the culture of the virus, the gene being under the control of the immediate early (IE1) gene enhancer of cytomegalovirus (CMV) and to the use of the recombinant HSV genome in therapy and vaccination.
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