Human Rnase H1 and oligonucleotide compositions thereof

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United States of America Patent

PATENT NO 6617442
SERIAL NO

09409926

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Abstract

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The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 92010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crooke, Stanley T Carlsbad, CA 155 5482
Lima, Walter F San Diego, CA 30 760
Monoharan, Muthiah Carlsbad, CA 3 117
Wu, Hongjiang Carlsbad, CA 59 273

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