Importance

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Abstract

The present invention provides devices and methods for inducing fibrin growth in tissue to promote revascularization of that tissue. The devices and methods are useful in ischemic tissue occurring anywhere in the body, and are particularly useful in treating ischemic myocardial tissue of the heart. The device may comprise a frame configured to foster a fibrin growth and configured to permit communication between the fibrin and the tissue into which the frame is implanted. The fibrin may be positioned internally or externally on the frame. The implant should be capable of becoming anchored in the tissue to prevent the formed fibrin from dislodging from the tissue. A fibrin producing substance may be associated with the implant device to help promote and sustain the fibrin growth. Alternatively, a thrombophilic or fibrin producing substance may be introduced into ischemic tissue alone, without an associated device, to induce fibrin growth in vivo. In another aspect of the invention, a thrombus formed ex vivo may be associated with the device prior to implantation to aid in revascularization by initiating angiogenesis and vessel recruitment. A thrombus formed ex vivo also may be introduced into the subject tissue without an associated implant device.

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First Claim