US Patent No: 6,620,627

Number of patents in Portfolio can not be more than 2000

Increased separation efficiency via controlled aggregation of magnetic nanoparticles

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Abstract

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Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters created by naturally occurring aggregators of colloidal magnetic particles. Additionally means for significantly enhancing the magnetic isolation of low antigen density target cells from biological samples are disclosed.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
IMMUNIVEST CORPORATIONRARITAN, NJ32
JANSSEN DIAGNOSTICS, LLCRARITAN, NJ47

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liberti, Paul A Huntingdon Valley, PA 36 2166
Rao, Galla Candra Princeton, NJ 2 60
Terstappen, Leon W M M Huntingdon Valley, PA 40 1234

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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COULTER INTERNATIONAL CORP. (1)
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JANSSEN DIAGNOSTICS, LLC (6)
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5,186,827 Apparatus for magnetic separation featuring external magnetic means 163 1991
5,622,831 Methods and devices for manipulation of magnetically collected material 56 1995
5,698,271 Methods for the manufacture of magnetically responsive particles 112 1995
6,013,188 Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force 80 1997
5,876,593 Magnetic immobilization and manipulation of biological entities 35 1997
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (2)
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MILTENYI BIOTEC GMBLL (1)
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UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (1)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
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VERIDEX, LLC (1)
5,466,574 Apparatus and methods for magnetic separation featuring external magnetic means 198 1993
 
MASSACHUSETTS GENERAL HOSPITAL (1)
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BIOVERIS CORPORATION (1)
6,146,838 Detecting water-borne parasites using electrochemiluminescence 19 1997
 
ABBOTT LABORATORIES (1)
* 6,207,380 Reagents and methods useful for detecting diseases of the urinary tract 14 1998
 
STEMCELL TECHNOLOGIES INC. (1)
* 6,117,985 Antibody compositions for preparing enriched cell preparations 59 1998
 
The Jackson Laboratory (1)
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The Terry Fox Laboratory of the British Columbia Cancer Agnecy (1)
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Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (1)
9,128,101 Biomarkers for theranostics 0 2011
 
Other [Check patent profile for assignment information] (1)
* 2011/0014,686 Method and apparatus for imaging target components in a biological sample using permanent magnets 4 2010
 
The Regents of the University of California (4)
7,998,923 Bioactivation of particles 2 2003
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* 2007/0153,280 Diagnostic imaging device for the analysis of circulating rare cells 0 2007
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AVIVA BIOSCIENCES CORPORATION (6)
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SWR&D INC. (5)
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WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
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GeneStream, Inc. (1)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
7,208,134 Bioprocesses enhanced by magnetic nanoparticles 6 2004
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VERIDEX, LLC (4)
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United States of America (1)
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DNA ELECTRONICS, INC. (3)
9,389,225 Separating target analytes using alternating magnetic fields 0 2010
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CITY UNIVERSITY OF HONG KONG (2)
7,754,444 Biofunctional magnetic nanoparticles for pathogen detection 0 2005
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NANOMR, INC. (1)
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