US Patent No: 6,620,627

Number of patents in Portfolio can not be more than 2000

Increased separation efficiency via controlled aggregation of magnetic nanoparticles

1 Status Updates

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters created by naturally occurring aggregators of colloidal magnetic particles. Additionally means for significantly enhancing the magnetic isolation of low antigen density target cells from biological samples are disclosed.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
IMMUNIVEST CORPORATIONRARITAN, NJ43
JANSSEN DIAGNOSTICS, LLCRARITAN, NJ47

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liberti, Paul A Huntingdon Valley, PA 37 1668
Rao, Galla Candra Princeton, NJ 2 41
Terstappen, Leon W M M Huntingdon Valley, PA 39 932

Cited Art Landscape

Patent Info (Count) # Cites Year
 
JANSSEN DIAGNOSTICS, LLC (6)
5,200,084 Apparatus and methods for magnetic separation 122 1990
5,186,827 Apparatus for magnetic separation featuring external magnetic means 133 1991
5,622,831 Methods and devices for manipulation of magnetically collected material 40 1995
5,698,271 Methods for the manufacture of magnetically responsive particles 94 1995
6,013,188 Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force 59 1997
5,876,593 Magnetic immobilization and manipulation of biological entities 25 1997
 
DADE BEHRING MARBURG GMBH (2)
4,812,401 Reversible agglutination mediators for separating cells from whole blood 7 1987
5,405,743 Reversible agglutination mediators 7 1994
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (2)
4,868,130 Methods for conducting specific binding assays 39 1987
6,121,055 Methods and devices for conducting specific binding assays 10 1995
 
ABBOTT LABORATORIES (1)
6,207,380 Reagents and methods useful for detecting diseases of the urinary tract 14 1998
 
BIOVERIS CORPORATION (1)
6,146,838 Detecting water-borne parasites using electrochemiluminescence 14 1997
 
COULTER INTERNATIONAL CORP. (1)
6,004,743 Method and apparatus for bulk enrichment of a population or subpopulation of cells 4 1997
 
MASSACHUSETTS GENERAL HOSPITAL (1)
4,973,669 Monoclonal IgM antibody with specificity against hepatitis B surface antigen 2 1988
 
MILTENYI BIOTEC GMBLL (1)
5,779,892 Magnetic separator with magnetic compensated release mechanism for separating biological material 13 1996
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,635,356 Anti-oncoimmunin-M antibodies and uses thereof 3 1994
 
STEMCELL TECHNOLOGIES INC. (1)
6,117,985 Antibody compositions for preparing enriched cell preparations 44 1998
 
TECHNICON INSTRUMENTS CORPORATION (1)
4,253,844 Insolubilized proteins and immunoassays utilizing them 21 1979
 
THE JACKSON LABORATORY (1)
5,665,582 Isolation of biological materials 105 1994
 
The Terry Fox Laboratory of the British Columbia Cancer Agnecy (1)
5,439,586 Magnetic filter with ordered wire array 13 1993
 
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (1)
6,150,181 Magnetic nanoparticles coupled to annexine, and utilization thereof 6 1998
 
VERIDEX, LLC (1)
5,466,574 Apparatus and methods for magnetic separation featuring external magnetic means 165 1993

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
JANSSEN DIAGNOSTICS, LLC (4)
8,337,755 Operator independent programmable sample preparation and analysis system 0 2006
7,777,885 Diagnostic imaging device for the analysis of circulating rare cells 2 2007
8,110,101 Method and apparatus for imaging target components in a biological sample using permanent magnets 3 2007
7,828,968 Method and apparatus for imaging target components in a biological sample using permanent magnets 4 2008
 
SWR&D INC. (3)
7,344,491 Method and apparatus for improving hearing 1 2004
7,819,795 Method and apparatus for improving hearing 0 2007
8,651,113 Magnetically responsive nanoparticle therapeutic constructs and methods of making and using 0 2009
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (3)
7,998,923 Bioactivation of particles 1 2003
7,943,396 Peptide-coated nanoparticles with graded shell compositions 1 2005
8,383,423 Peptide-coated nanoparticles with graded shell compositions 0 2011
 
NANOMR, INC. (2)
8,710,836 NMR, instrumentation, and flow meter/controller continuously detecting MR signals, from continuously flowing sample material 0 2009
8,841,104 Methods for isolating a target analyte from a heterogeneous sample 0 2011
 
AVIVA BIOSCIENCES CORPORATION (1)
8,569,009 Methods and compositions for detecting rare cells from a biological sample 0 2007
 
CITY UNIVERSITY OF HONG KONG (1)
7,754,444 Biofunctional magnetic nanoparticles for pathogen detection 0 2005
 
GeneStream, Inc. (1)
8,790,916 Microfluidic method and system for isolating particles from biological fluid 0 2010
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
7,208,134 Bioprocesses enhanced by magnetic nanoparticles 4 2004
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
7,790,473 Biofunctionalized quantum dots for biological imaging 1 2003
 
VERIDEX, LLC (1)
8,329,422 Analysis of circulating tumor cells, fragments, and debris 0 2010

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Mar 16, 2015
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00