US Patent No: 6,623,963

Number of patents in Portfolio can not be more than 2000

Cellular matrix

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Abstract

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A biocompatible, resorbable Type II collagen-based matrix is reconstituted from solubilized animal cartilage tissue and used in the culture and growth of cells, such as chondrocyte cells. The matrix is produced by isolating cartilage tissue, solubilizing and reconstituting the cartilage to form a fleece-like material, pressing the fleece-like material to form a sheet-like article, and sterilizing the article. An implantable article for cartilage repair includes chondrocyte cells retained on the matrix.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
VERICEL CORPORATIONCAMBRIDGE, MA20
BEHRENS, PETER51377 LEVERKUSEN1
MULLER, PETER KARL51377 LEVERKUSEN1
ROHWEDEL, JURGEN51377 LEVERKUSEN1
RUSSLIES, MARTIN51377 LEVERKUSEN1

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Behrens, Peter Aegidiensir 51, 23552 Lubeck, DE 5 154
Giannetti, Bruno Bonn, DE 17 479
Muller, Peter Karl Auf dem Vorbeck 25, 29562 Lubeck, DE 1 29
Rohwedel, Jurgen Huexatr 112-116, 23552 Lubeck, DE 2 29
Russlies, Martin Gustav-Falke-Sir 16B, 23562 Lubeck, DE 2 29

Cited Art Landscape

Patent Info (Count) # Cites Year
 
REGEN BIOLOGICS, INC. (1)
5,735,902 Hand implant device 8 1996
 
COLLAGEN AESTHETICS, INC. (2)
4,424,208 Collagen implant material and method for augmenting soft tissue 292 1982
4,488,911 Non-antigenic collagen and articles of manufacture 123 1983
 
SMITH & NEPHEW, INC. (2)
5,902,741 Three-dimensional cartilage cultures 174 1995
5,842,477 Method for repairing cartilage 434 1996
 
OSTEOMEDICAL LIMITED (1)
4,882,149 Pharmaceutical depot preparation 56 1988
 
COHESION TECHNOLOGIES, INC. (2)
4,582,640 Injectable cross-linked collagen implant material 289 1984
4,642,117 Mechanically sheared collagen implant material and method 179 1985
 
GEISTLICH PHARMA AG (1)
5,837,278 Resorbable collagen membrane for use in guided tissue regeneration 60 1996
 
Colla-Tec, Incorporated (1)
5,206,028 Dense collagen membrane matrices for medical uses 146 1991
 
ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIE (1)
5,076,265 Hydrogel sheet wound dressings 26 1989
 
ReGen Corporation (3)
5,116,374 Prosthetic meniscus 80 1990
5,158,574 Prosthetic meniscus 76 1991
5,258,043 Method for making a prosthetic intervertebral disc 235 1991
 
GENSCI ORTHOBIOLOGICS, INC. (2)
4,394,370 Bone graft material for osseous defects and method of making same 403 1981
4,472,840 Method of inducing osseous formation by implanting bone graft material 269 1982
 
IVY SPORTS MEDICINE, LLC (1)
5,677,284 Charged collagen particle-based delivery matrix 20 1995
 
SOCIETE ANONYME DE DEVELOPMENT DES UTILISATIONS DU CUIR-SADUC (3)
4,931,546 Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said process 38 1987
5,201,745 Visceral surgery patch 89 1991
5,618,551 Biocompatible bioresorbable and non-toxic adhesive composition for surgical use 60 1995
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Mitsuo Ochi (1)
* 2007/0172,812 Tissue equivalent for transplantation and method for producing same 4 2007
 
Other [Check patent profile for assignment information] (3)
* 2006/0111,778 Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway 20 2005
8,377,432 Method and composition for neochondrogenesis 0 2010
* 2011/0052,526 METHOD AND COMPOSITION FOR NEOCHONDROGENESIS 0 2010
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
* 2006/0172,412 Support device for cells culture 11 2005
 
VERIGEN AG (2)
* 2004/0136,968 Autologous cells on a support matrix for tissue repair 18 2003
* 2006/0159,665 Seed tear resistant scaffold 1 2005
 
TAIPEI MEDICAL UNIVERSITY (2)
8,431,399 Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro 0 2010
* 2011/0217,773 METHOD TO RESTORE CARTILAGINOUS PHENOTYPE OF CHONDROCYTES AFTER CULTURED AND EXPANDED IN VITRO 0 2010
 
ZIMMER, INC. (2)
9,289,302 Mosaicplasty constructs 0 2009
* 2010/0161,073 MOSAICPLASTY CONSTRUCTS 1 2009
 
PHILLIPS, FRANK M. (1)
8,697,139 Method of intervertebral disc treatment using articular chondrocyte cells 0 2004
 
GENZYME CORPORATION (1)
* 2011/0262,516 AUTOLOGOUS CELLS ON A SUPPORT MATRIX FOR TISSUE REPAIR 0 2011
 
PHILLIPS PLASTICS CORPORATION (2)
8,062,655 Composite scaffold structure 0 2007
* 2009/0062,821 COMPOSITE SCAFFOLD STRUCTURE 1 2007
 
PENTAX CORPORATION (1)
* 2006/0212,125 Bone repairing material using a chondrocyte having the potential for hypertrophy and a scaffold 2 2006
 
SYNOVIS ORTHOPEDIC AND WOUNDCARE, INC. (5)
* 2007/0218,038 STABILIZED, STERILIZED COLLAGEN SCAFFOLDS WITH ACTIVE ADJUNCTS ATTACHED 2 2007
* 2009/0018,655 Composite Implant for Surgical Repair 71 2007
* 9,387,280 Device for soft tissue repair or replacement 0 2008
* 2010/0063,599 DEVICE FOR SOFT TISSUE REPAIR OR REPLACEMENT 3 2008
* 2009/0196,898 STABILIZED, STERILIZED COLLAGEN SCAFFOLDS WITH ACTIVE ADJUNCTS ATTACHED 0 2009
 
HOWMEDICA OSTEONICS CORP. (1)
* 2007/0299,517 Articular cartilage implant 24 2006
 
Taipei Biotechnology Ltd., Inc. (2)
* 6,852,331 Fabrication of a cartilage implant 11 2002
* 2003/0152,556 Fabrication of a cartilage implant 2 2002
 
PFIZER INC. (1)
* 2003/0191,107 3-(Imidazolyl)-2-aminopropanoic acids 2 2003
 
SHIMIZU, YASUHIKO (2)
* 7,011,829 Tissue filler 1 2001
* 2004/0028,659 Tissue filler 0 2003
 
SOFRADIM PRODUCTION (4)
9,308,068 Implant for parastomal hernia 0 2008
9,242,026 Biosynthetic implant for soft tissue repair 0 2009
9,445,883 Barbed prosthetic knit and hernia repair mesh made therefrom as well as process for making said prosthetic knit 0 2012
9,499,927 Method for producing a prosthesis for reinforcing the abdominal wall 0 2013
 
Zimmer Orthobiologics, Inc. (4)
8,173,162 Preparation for repairing cartilage tissue, especially articular cartilage defects 2 2004
* 2007/0148,242 Preparation for repairing cartilage tissue, especially articular cartilage defects 14 2004
8,945,535 Implant for the repair of a cartilage defect and method for manufacturing the implant 4 2006
* 2008/0269,895 Implant for the Repair of a Cartilage Defect and Method for Manufacturing the Implant 5 2006
 
WARSAW ORTHOPEDIC, INC. (7)
* 2004/0054,414 Collagen-based materials and methods for augmenting intervertebral discs 70 2002
7,744,651 Compositions and methods for treating intervertebral discs with collagen-based materials 2 2005
7,713,303 Collagen-based materials and methods for augmenting intervertebral discs 3 2005
8,399,619 Injectable collagen material 0 2006
8,118,779 Collagen delivery device 0 2006
7,731,981 Collagen-based materials and methods for treating synovial joints 2 2007
* 2012/0276,202 COLLAGEN MATRIX FOR TISSUE ENGINEERING 0 2011
 
MUSCULOSKELETAL TRANSPLANT FOUNDATION (10)
7,901,457 Cartilage allograft plug 34 2003
7,488,348 Cartilage allograft plug 32 2005
7,815,926 Implant for articular cartilage repair 9 2006
7,837,740 Two piece cancellous construct for cartilage repair 26 2007
RE42208 Glue for cartilage repair 19 2008
8,221,500 Cartilage allograft plug 7 2008
8,435,551 Cancellous construct with support ring for repair of osteochondral defects 3 2009
8,906,110 Two piece cancellous construct for cartilage repair 0 2010
RE43258 Glue for cartilage repair 5 2010
8,292,968 Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 7 2011
* Cited By Examiner