Compounds selectively inhibiting gamma 9 delta 2 T lymphocytes
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United States of America Patent
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Sep 23, 2003
Issued Date -
N/A
app pub date -
Dec 20, 2001
filing date -
Apr 6, 1999
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Expired
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Abstract
The invention concerns compounds CH.sub.3 --R.sub.1 --(CH.sub.1).sub.2 --R.sub.2 wherein: R.sub.1 is selected among a tertiary alcohol; a 1,2-diol; a halohydrine; an apoxide; an alkene; an aldehyde or an .alpha.-hydroxyaldehyde; and R.sub.2 is selected among a methylenediphosphonate; a difluoromethylenediphosphonate; or a monofluoromethylenediphosphoneate. The invention also concerns the uses of said compounds as selective inhibitors of T.gamma.9.delta.2 lymphocytes, and their uses, in particular for therapeutic purposes.
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