Controlled release liquid delivery compositions with low initial drug burst
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United States of America Patent
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Oct 7, 2003
Issued Date -
N/A
app pub date -
Aug 22, 2000
filing date -
Oct 28, 1998
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Abstract
The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.
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