Cell-culture and polymer constructs

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United States of America Patent

PATENT NO 6637437
SERIAL NO

09712662

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is directed to the culture of cells, and particularly chondrocytes for purpose of tissue replacement. The cells are cultured on polymer constructs. Integren expression is used as a measure of chondrocyte viability. Chondrocytes are obtained from the knee, nose and ankle cartilage. Mechanical strain is used to propagate chondrocytes, chitosan and arabinogalactanchitosan are used as scaffolds. Progenitor, pluripotential, stem and mesenchymal cells are operative in this invention.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY;CHONDROS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Domb, Abraham J Efrat, IL 103 5523
Frondoza, Carmelita G Woodstock, MD 9 523
Hungerford, David S Cockeysville, MD 14 827
Shikani, Alan H Ruxton, MD 19 798

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