Therapeutic coating for an intravascular implant
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United States of America Patent
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-
Nov 4, 2003
Grant Date -
May 29, 2003
app pub date -
Nov 26, 2001
filing date -
Nov 26, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to a coating for an intravascular implant that prevents hyperproliferative vascular disease after a mechanical injury, such as angioplasty. The coating includes first and second agents, with the first agent acting on a calcium independent cellular pathway and the second agent acting on a calcium dependent cellular pathway. In an exemplary embodiment, the first agent is rapamycin and the second agent is cyclosporine A. The agents can be incorporated in a polymeric agent and can be applied either directly to the implant or on top of a primer layer placed on the implant. A top coat can be applied to the therapeutic coating, if desired.
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