Vectors and genes exhibiting increased expression
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United States of America Patent
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Nov 4, 2003
Grant Date -
N/A
app pub date -
Dec 4, 1998
filing date -
Dec 5, 1997
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Expired
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Abstract
Novel genes and vectors exhibiting increased expression and novel splicing patterns are disclosed. The gene can comprise one or more consensus or near consensus splice sites which have been corrected. The gene can alternatively or additionally comprise one or more introns within coding or noncoding sequences. The gene can still further comprise modified 5' and/or 3' untranslated regions optimized to provide high levels and duration of tissue-specific expression. In one embodiment, the gene comprises the coding region of a full-length Factor VIII gene modified by adding an intron within the portion of the gene encoding the .beta.-domain, so that the gene is expressed as a .beta.-domain deleted Factor VIII protein. The novel Factor VIII gene can also be modified to correct one or more consensus or near consensus splice sites within or outside of the coding region.
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