Methods and reagents for the rapid and efficient isolation of circulating cancer cells

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6645731
APP PUB NO 20020009759A1
SERIAL NO

09904472

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Abstract

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A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P AVIA GIUSEPPE DI VITTORIO 21 B/3 CASTEL MAGGIORE BOLOGNA 40013

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liberti, Paul A Huntingdon Valley, PA 38 3054
Racila, Emilian V Dallas, TX 6 434
Rao, Galla Chandra Princeton, NJ 31 1339
Terstappen, Leon W M M Huntington Valley, PA 41 2020
Uhr, Jonathan W Dallas, TX 17 867

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