Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
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United States of America Patent
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Nov 18, 2003
Grant Date -
N/A
app pub date -
Apr 27, 2000
filing date -
Apr 30, 1999
priority date (Note) -
Expired
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Abstract
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
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