High efficiency gene targeting in mouse embryonic stem cells
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United States of America Patent
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Nov 25, 2003
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app pub date -
Feb 19, 1999
filing date -
Aug 20, 1991
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Abstract
The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a 'targeting DNA') that is substantially isogenic with a DNA in the cell genome (a 'target DNA'); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.
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