Magnetic separation apparatus and methods

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United States of America Patent

PATENT NO 6660159
SERIAL NO

09856672

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Abstract

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Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel having a chamber therein, the vessel comprising a transparent collection wall. A high internal gradient magnetic capture structure may be on the transparent collection wall, magnets create an externally-applied force for transporting magnetically responsive material toward the transparent collection wall. The magnetic capture structure comprises a plurality of ferromagnetic members and has a uniform or non-nonuniform spacing between adjacent members. There may be electrical conductor means supported on the transparent collection wall for enabling electrical manipulation of the biological substances. The chamber has one compartment or a plurality of compartments with differing heights. The chamber may include a porous wall. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P A40013 CASTEL MAGGIORE (BO)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dolan, Gerald Huntingdon Valley, PA 5 204
Terstappen, Leon W M M Huntingdon Valley, PA 41 2272

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