Therapeutic inhibitor of vascular smooth muscle cells
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United States of America Patent
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-
Dec 16, 2003
Grant Date -
Jul 4, 2002
app pub date -
Dec 18, 2001
filing date -
Jan 28, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
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