Alpha or beta emitters attached to fragments in radioimmunotherapy
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United States of America Patent
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Dec 23, 2003
Grant Date -
N/A
app pub date -
Jun 7, 2000
filing date -
Jun 7, 1999
priority date (Note) -
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Abstract
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta-emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient.
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