Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
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United States of America Patent
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Dec 23, 2003
Grant Date -
May 8, 2003
app pub date -
Sep 11, 2001
filing date -
Sep 11, 2001
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Expired
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Abstract
The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures: ##STR1## with X, Y, D, Q, V, A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and n.sub.1 defined herein.
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