Transdermal and topical administration of local anesthetic agents using basic enhancers
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United States of America Patent
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Jan 6, 2004
Grant Date -
Dec 26, 2002
app pub date -
Jun 19, 2002
filing date -
Dec 16, 1999
priority date (Note) -
Expired
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Abstract
Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of local anesthetic agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.
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