Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
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United States of America Patent
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Jan 6, 2004
Grant Date -
Oct 3, 2002
app pub date -
May 25, 2001
filing date -
Apr 20, 1998
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Abstract
This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
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