2'-O-aminoethyloxyethyl-modified oligonucleotides
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United States of America Patent
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Jan 6, 2004
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N/A
app pub date -
Apr 11, 2002
filing date -
Aug 7, 1998
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Abstract
2'-O-Modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed. Oligomeric compounds are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.
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