Production of a multimeric protein by cell fusion method
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United States of America Patent
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Jan 13, 2004
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app pub date -
Aug 30, 2001
filing date -
Oct 11, 1996
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Abstract
The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
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