Elongase genes and uses thereof
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United States of America Patent
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Jan 13, 2004
Grant Date -
Sep 26, 2002
app pub date -
Jul 11, 2001
filing date -
Sep 2, 1998
priority date (Note) -
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Abstract
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., 'elongases') and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to .omega.3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, .omega.6-docosapentaenoic acid or .omega.3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
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