Methods for identifying agents that interact with an active site of acyl carrier protein synthase-acyl carrier protein complex
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United States of America Patent
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Jan 27, 2004
Grant Date -
Nov 13, 2003
app pub date -
Jan 25, 2001
filing date -
May 8, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
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