Protein formulation
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United States of America Patent
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-
Feb 3, 2004
Grant Date -
Aug 16, 2001
app pub date -
Mar 14, 2001
filing date -
Jul 27, 1995
priority date (Note) -
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Abstract
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
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