Conjugated peptide nucleic acids having enhanced cellular uptake
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United States of America Patent
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Feb 3, 2004
Issued Date -
N/A
app pub date -
Nov 19, 2001
filing date -
Apr 26, 1993
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Expired
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Abstract
Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
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