Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide
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United States of America Patent
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Feb 10, 2004
Grant Date -
Feb 27, 2003
app pub date -
Jul 25, 2002
filing date -
Aug 21, 2001
priority date (Note) -
Expired
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Abstract
The present invention pertains to a method for treating a pulmonary disease state in mammals by altering indigenous in vivo levels of nitric oxide in mammalian cells. The method comprises contacting the mammalian cells with a therapeutically effective amount of a nitric oxide mediator selected from the group consisting of pyruvates, pyruvate precursors, .alpha.-keto acids having four or more carbon atoms, precursors of .alpha.-keto acids having four or more carbon atoms, and the salts thereof. The method may further comprise contacting the mammalian cells with a therapeutic agent and a nitric oxide source selected from the group consisting of nitric oxide, nitric oxide precursors, and nitric oxide stimulators.
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