ErbB2 and ErbB4 Chimeric Heteromultimeric Adhesins
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United States of America Patent
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Feb 24, 2004
Grant Date -
Oct 23, 2003
app pub date -
Mar 12, 1999
filing date -
Jul 12, 1996
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Abstract
Novel chimeric heteromultimer adhesins that bind the ligand of natural heteromultimeric receptors and uses therefor are disclosed. The chimeric molecules of the heteromultimer adhesins comprise an extracellular domain of a heteromultimeric receptor monomer and a multimerization domain for the stable interaction of the chimeric molecules in the adhesin. Specifically disclosed are heteromultimeric adhesins comprising the extracellular domains of ErbB2 and ErbB3 or ErbB2 and ErbB4. The chimeric ErbB heteromultimer adhesins of the present invention are useful as competitive antagonists or agonists of a neuregulin for the treatment of diseases such as various cancers.
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