Non-oxidizable bilirubin substitutes and uses therefor
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United States of America Patent
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Feb 24, 2004
Grant Date -
Oct 10, 2002
app pub date -
Feb 13, 2001
filing date -
Feb 13, 2001
priority date (Note) -
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Abstract
Compositions and methods are disclosed for use in the analysis and quantitation of conjugated and unconjugated bilirubin in patient or other samples. The compositions have the general formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently selected from alkyl and aryl, R.sup.3 and R.sup.4 are independently selected from hydrogen, alkyl, alkenyl, tauryl, aryl, and glucoronyl, and R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are each independently selected from hydrogen and alkyl, and are resistant to oxidation, as occurs in bilirubin upon exposure to light and air. These properties make them ideal for use in calibration and control solutions for use in medical and research bilirubin analysis, or other applications where stable reagents for bilirubin analysis is desirable.
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