Mesh-gel constructs for cell delivery containing enzymes and/or enzyme inhibitors to control gel degradation
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United States of America Patent
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Mar 2, 2004
Grant Date -
N/A
app pub date -
Oct 10, 2000
filing date -
Oct 12, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A cell delivery device is prepared comprising a controllable degradable gel phase, meshed within a polymer substrate for use in tissue-engineering. The gel phase comprises a degradable, natural or synthetic polymer, and includes a suspension of living cells. The polymer substrate comprises a biocompatible, degradable polymer, and may be synthetic or natural. Degradation of the gel phase may be controlled by enzyme activity or adjustment of gel phase physical properties. In one embodiment, the gel phase contains an enzyme and/or enzyme inhibitor to control degradation of the gel phase. The device is useful in tissue replacement and repair, and more particularly, in the repair of cartilage tissue.
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