Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
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United States of America Patent
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Mar 9, 2004
Issued Date -
N/A
app pub date -
Sep 27, 1999
filing date -
Apr 28, 1994
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Expired
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Abstract
The subject invention concerns new methods which make it possible, for the first time, to grow functional islet-producing stem cells (IPSCs), islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in in vitro cultures. The subject invention also concerns the use of the in vitro grown IPSCs, IPCs and/or IdIs for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process of using the implanted cells for growing a pancreas-like structure in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic endocrine tissue. The ability to grow these cells in vitro and pancreas-like structures in vivo opens up important new avenues for research and therapy relating to diabetes.
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