Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
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United States of America Patent
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Mar 9, 2004
Grant Date -
N/A
app pub date -
May 15, 1998
filing date -
May 15, 1997
priority date (Note) -
Expired
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Abstract
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
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