Osmotically stabilized microbubble preparations
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United States of America Patent
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Mar 16, 2004
Issued Date -
N/A
app pub date -
May 21, 2001
filing date -
Jul 30, 1993
priority date (Note) -
Expired
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Abstract
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
First Claim
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
TARGESON INC | 325 BARRACKS HILL CHARLOTTESVILLE VA 22901 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Anderson, Charles David | 27 Potterstown Rd., Lebanon, NJ 08833 | 14 | 333 |
Evitts, David P | 8440-C Via Mallorca, La Jolla, CA 92037 | 16 | 524 |
Kinner, Rene Alta | 3955 Third Ave., San Diego, CA 92103 | 8 | 170 |
Schutt, Ernest G | 12139 Ragweed St., San Diego, CA 92129 | 75 | 3023 |
Weers, Jeffry G | 12191 Salix Way, San Diego, CA 92129 | 63 | 2061 |
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Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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