Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof
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United States of America Patent
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Mar 23, 2004
Grant Date -
Nov 7, 2002
app pub date -
Mar 5, 2001
filing date -
Feb 28, 2001
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention is directed to a pharmaceutical composition comprising F(ab').sub.2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab').sub.2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized, as a source of antibodies. The serum or blood plasma is digested with pepsin, followed by separation and purification until the pharmaceutical composition of F(ab').sub.2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
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