4-hydroxypiperidine derivatives having antiarrhythmic activity
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United States of America Patent
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Mar 23, 2004
Issued Date -
N/A
app pub date -
Oct 4, 2001
filing date -
Apr 9, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: ##STR1## (wherein A represents, for example, phenyl group substituted with R.sup.1 and R.sup.2 or unsubstituted thienyl group; R.sup.1 and R.sup.2 each independently represent, for example, hydrogen atom, halogen atom or lower alkoxycarbonyl group; R.sup.3 represents, for example, hydrogen atom; R.sup.4 represents, for example, lower alkyl group; R.sup.5 represents, for example, lower alkoxy group; R.sup.6 represents, for example, hydrogen atom; R.sup.7 and R.sup.8 each represent, for example, hydrogen atom, respectively; X represents, for example, a single bond; Y represents, for example, methylene group or benzylidene group substituted with R.sup.1 ; and Z represents, for example, methylene group.) The compounds according to the present invention that do not suppress the transient sodium current of the cardiac muscle and do not manifest proarrhythimic activity is useful as a therapeutic agent for preventing and/or treating arrhythimia and for preventing sudden death.
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