Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
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United States of America Patent
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Mar 23, 2004
Grant Date -
N/A
app pub date -
Mar 10, 1999
filing date -
Nov 22, 1993
priority date (Note) -
Expired
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Abstract
A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.
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