Methods for increasing vascularization and promoting wound healing
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United States of America Patent
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Mar 30, 2004
Issued Date -
N/A
app pub date -
Jan 19, 2001
filing date -
Feb 24, 1992
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Abstract
The present invention provides a method of stimulating vascularization at a site in a mammal, said method comprising contacting said site with a matrix comprising gelatin and a nitric oxide inhibitor. The gelatin is preferably denatured collagen. The nitric oxide inhibitor may be a sulfonated moiety. The inhibitor may be an L-arginine analog, such as aminoguanidine, N-monoethyl L-arginine, N-nitro-L-arginine and D-arginine. The matrix may further comprise a nitric oxide scavenger, such as dextran, heparin, cysteine and cystine.
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