US Patent No: 6,713,119

Number of patents in Portfolio can not be more than 2000

Biocompatible coating for a prosthesis and a method of forming the same

ALSO PUBLISHED AS: 20020193475
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Abstract

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A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ADVANCED CARDIOVASCULAR SYSTEMS, INC.SANTA CLARA, CA1584

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Castro, Daniel A Santa Clara, CA 16 270
Guruwaiya, Judy A San Jose, CA 32 2597
Harish, Sameer Fremont, CA 19 2396
Hossainy, Syed F A Fremont, CA 212 8471
Sanders-Millare, Deborra San Jose, CA 16 2037
Wu, Steven Z Santa Clara, CA 24 3060

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MICRO THERAPEUTICS, INC. (4)
5,667,767 Compositions for use in embolizing blood vessels 464 1995
5,830,178 Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide 460 1996
5,851,508 Compositions for use in embolizing blood vessels 391 1997
6,015,541 Radioactive embolizing compositions 403 1997
 
BOSTON SCIENTIFIC SCIMED, INC. (3)
5,837,313 Drug release stent coating process 669 1996
5,980,972 Method of applying drug-release coatings 471 1997
6,258,121 Stent coating 424 1999
 
MED INSTITUTE, INC. (3)
6,096,070 Coated implantable medical device 808 1996
5,824,049 Coated implantable medical device 771 1996
5,873,904 Silver implantable medical device 771 1997
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (2)
5,605,696 Drug loaded polymeric material and method of manufacture 624 1995
5,700,286 Polymer film for wrapping a stent structure 619 1996
 
MEDTRONIC, INC. (2)
4,886,062 Intravascular radially expandable stent and method of implant 1313 1987
5,865,814 Blood contacting medical device and method 411 1997
 
VENTION MEDICAL ADVANCED COMPONENTS, INC. (2)
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5,800,392 Microporous catheter 265 1996
 
ANGIOTECH BIOCOATINGS CORP. (1)
5,716,981 Anti-angiogenic compositions and methods of use 702 1995
 
BOSTON SCIENTIFIC TECHNOLOGY, INC. (1)
6,010,530 Self-expanding endoluminal prosthesis 327 1998
 
COOK INCORPORATED (1)
4,800,882 Endovascular stent and delivery system 1277 1987
 
ETHICON, INC. (1)
6,153,252 Process for coating stents 668 1999
 
EXPANDABLE GRAFTS PARTNERSHIP, 8000 I.H. 10 WEST, STE. 1265, SAN ANTONIO, TX A GENERAL PARTNERSHIP OF TX. (1)
4,733,665 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 2258 1985
 
GENZYME CORPORATION (1)
5,328,471 Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens 523 1993
 
LATHAM, DANIEL W. (1)
5,464,650 Intravascular stent and method 791 1993
 
LIFEPORT SCIENCES LLC (1)
6,165,212 Expandable supportive endoluminal grafts 413 1999
 
Minnesota Mining and Manufacturing Company (1)
4,977,901 Article having non-crosslinked crystallized polymer coatings 368 1990
 
Rochester Medical Corporation (1)
5,971,954 Method of making catheter 359 1997
 
TERUMO KABUSHIKI KAISHA (1)
5,670,558 Medical instruments that exhibit surface lubricity when wetted 385 1995
 
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (1)
5,578,073 Thromboresistant surface treatment for biomaterials 362 1994
 
Other [Check patent profile for assignment information] (1)
5,980,928 Implant for preventing conjunctivitis in cattle 366 1997

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (116)
7,682,669 Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device 1 2001
8,303,651 Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 1 2001
8,506,617 Micronized peptide coated stent 0 2002
7,217,426 Coatings containing polycationic peptides for cardiovascular therapy 33 2002
7,070,798 Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine 16 2002
7,056,523 Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine 11 2002
7,033,602 Polycationic peptide coatings and methods of coating implantable medical devices 13 2002
7,011,842 Polycationic peptide coatings and methods of making the same 7 2002
6,994,867 Biocompatible carrier containing L-arginine 50 2002
7,087,263 Rare limiting barriers for implantable medical devices 17 2002
7,776,926 Biocompatible coating for implantable medical devices 32 2002
7,094,256 Coatings for implantable medical device containing polycationic peptides 37 2002
7,258,891 Stent mounting assembly and a method of using the same to coat a stent 20 2003
7,279,174 Stent coatings comprising hydrophilic additives 77 2003
7,431,959 Method and system for irradiation of a drug eluting implantable medical device 13 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 62 2003
8,192,752 Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same 2 2003
7,220,816 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 46 2003
7,435,788 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 10 2003
7,563,324 System and method for coating an implantable medical device 37 2003
7,820,190 Coating for implantable devices and a method of forming the same 7 2004
8,685,431 Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same 0 2004
8,349,388 Method of coating a stent 1 2004
7,758,880 Biocompatible polyacrylate compositions for medical applications 0 2004
7,364,748 Controlled morphologies in polymer drug for release of drugs from polymer films 3 2004
7,485,334 Stent mandrel fixture and method for minimizing coating defects 4 2004
6,972,054 Coupling device for a stent support fixture 30 2004
7,807,210 Hemocompatible polymers on hydrophobic porous polymers 4 2004
7,553,377 Apparatus and method for electrostatic coating of an abluminal stent surface 15 2004
8,293,890 Hyaluronic acid based copolymers 0 2004
7,820,732 Methods for modulating thermal and mechanical properties of coatings on implantable devices 6 2004
7,785,512 Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices 10 2004
7,807,211 Thermal treatment of an implantable medical device 7 2004
7,563,780 Heparin prodrugs and drug delivery stents formed therefrom 4 2004
7,077,860 Method of reducing or eliminating thrombus formation 27 2004
7,297,159 Selective coating of medical devices 9 2004
8,357,391 Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages 3 2004
7,494,665 Polymers containing siloxane monomers 5 2004
7,311,980 Polyactive/polylactic acid coatings for an implantable device 20 2004
7,648,727 Methods for manufacturing a coated stent-balloon assembly 5 2004
7,244,443 Polymers of fluorinated monomers and hydrophilic monomers 15 2004
8,110,211 Medicated coatings for implantable medical devices including polyacrylates 1 2004
8,052,912 Temperature controlled crimping 1 2004
7,166,680 Blends of poly(ester amide) polymers 25 2004
7,481,835 Encapsulated covered stent 7 2004
7,390,497 Poly(ester amide) filler blends for modulation of coating properties 15 2004
7,214,759 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 13 2004
8,609,123 Derivatized poly(ester amide) as a biobeneficial coating 0 2004
7,892,592 Coating abluminal surfaces of stents and other implantable medical devices 2 2004
7,632,307 Abluminal, multilayer coating constructs for drug-delivery stents 9 2004
7,604,818 Polymers of fluorinated monomers and hydrocarbon monomers 0 2004
8,741,378 Methods of coating an implantable device 0 2004
7,419,504 Poly(ester amide) block copolymers 9 2004
8,007,775 Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same 3 2004
7,202,325 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 30 2005
7,387,810 Method of forming rate limiting barriers for implantable devices 12 2005
7,063,884 Stent coating 25 2005
7,758,881 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 2 2005
7,795,467 Bioabsorbable, biobeneficial polyurethanes for use in medical devices 8 2005
8,778,375 Amorphous poly(D,L-lactide) coating 0 2005
7,637,941 Endothelial cell binding coatings for rapid encapsulation of bioerodable stents 24 2005
7,691,401 Poly(butylmethacrylate) and rapamycin coated stent 27 2005
7,622,070 Method of manufacturing an implantable polymeric medical device 42 2005
7,823,533 Stent fixture and method for reducing coating defects 3 2005
8,021,676 Functionalized chemically inert polymers for coatings 3 2005
8,067,023 Implantable medical devices incorporating plasma polymerized film layers and charged amino acids 0 2005
7,785,647 Methods of providing antioxidants to a drug containing product 0 2005
7,735,449 Stent fixture having rounded support structures and method for use thereof 12 2005
7,875,286 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,803,406 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,794,743 Polycationic peptide coatings and methods of making the same 3 2005
7,985,440 Method of using a mandrel to coat a stent 5 2005
7,396,541 Heparin prodrugs and drug delivery stents formed therefrom 2 2005
7,976,891 Abluminal stent coating apparatus and method of using focused acoustic energy 4 2005
7,591,841 Implantable devices for accelerated healing 2 2005
7,867,547 Selectively coating luminal surfaces of stents 0 2005
7,638,156 Apparatus and method for selectively coating a medical article 25 2005
7,601,383 Coating construct containing poly (vinyl alcohol) 2 2006
7,713,637 Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer 2 2006
8,304,012 Method for drying a stent 1 2006
8,069,814 Stent support devices 4 2006
8,003,156 Rotatable support elements for stents 7 2006
7,648,725 Clamp mandrel fixture and a method of using the same to minimize coating defects 3 2006
7,572,336 Clamp mandrel fixture and a method of using the same to minimize coating defects 2 2006
7,775,178 Stent coating apparatus and method 1 2006
8,568,764 Methods of forming coating layers for medical devices utilizing flash vaporization 0 2006
8,703,167 Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug 0 2006
8,778,376 Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating 0 2006
8,114,150 RGD peptide attached to bioabsorbable stents 1 2006
7,357,793 Polymers of fluorinated and hydrophilic monomers 27 2006
8,173,199 40-O-(2-hydroxy)ethyl-rapamycin coated stent 1 2006
7,803,394 Polycationic peptide hydrogel coatings for cardiovascular therapy 0 2006
7,365,133 Blends of poly(ester amide) polymers 0 2006
8,597,673 Coating of fast absorption or dissolution 1 2006
8,197,879 Method for selectively coating surfaces of a stent 0 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 1 2007
7,361,726 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 5 2007
8,067,025 Nitric oxide generating medical devices 1 2007
7,538,180 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 1 2007
7,901,703 Polycationic peptides for cardiovascular therapy 0 2007
8,017,140 Drug-delivery stent formulations for restenosis and vulnerable plaque 0 2007
7,766,884 Polymers of fluorinated monomers and hydrophilic monomers 0 2007
7,520,891 Blends of poly(ester amide) polymers 1 2008
7,507,251 Blends of poly(ester amide) polymers 0 2008
7,699,889 Poly(ester amide) block copolymers 0 2008
7,887,871 Method and system for irradiation of a drug eluting implantable medical device 0 2008
7,786,249 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,772,359 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,632,914 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
8,580,180 Polymeric stent polishing method and apparatus 0 2009
8,586,125 Thermal treatment of an implantable medical device 1 2010
8,293,367 Nanoshells on polymers 1 2011
8,741,379 Rotatable support elements for stents 0 2011
8,637,110 Rotatable support elements for stents 0 2011
8,596,215 Rotatable support elements for stents 0 2011
8,465,789 Rotatable support elements for stents 0 2011
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (35)
8,778,014 Coatings for preventing balloon damage to polymer coated stents 0 2004
8,586,069 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders 0 2005
7,985,441 Purification of polymers for coating applications 3 2006
8,603,530 Nanoshell therapy 0 2006
8,048,448 Nanoshells for drug delivery 1 2006
8,017,237 Nanoshells on polymers 3 2006
7,569,655 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 4 2007
8,029,816 Medical device coated with a coating containing elastin pentapeptide VGVPG 13 2007
8,147,769 Stent and delivery system with reduced chemical degradation 1 2007
8,109,904 Drug delivery medical devices 1 2007
8,048,441 Nanobead releasing medical devices 1 2007
8,703,169 Implantable device having a coating comprising carrageenan and a biostable polymer 0 2007
8,007,857 Methods for controlling the release rate and improving the mechanical properties of a stent coating 1 2007
8,673,334 Stent coatings comprising hydrophilic additives 0 2007
7,749,263 Poly(ester amide) filler blends for modulation of coating properties 0 2008
8,118,863 RGD peptide attached to bioabsorbable stents 0 2008
8,062,350 RGD peptide attached to bioabsorbable stents 0 2008
8,435,550 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 0 2008
8,226,603 Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 1 2008
8,049,061 Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery 2 2008
8,076,529 Expandable member formed of a fibrous matrix for intraluminal drug delivery 0 2008
8,603,634 End-capped poly(ester amide) copolymers 0 2009
8,183,337 Method of purifying ethylene vinyl alcohol copolymers for use with implantable medical devices 0 2009
8,389,041 Systems and methods for rotating and coating an implantable device 1 2010
8,647,655 Biocompatible polyacrylate compositions for medical applications 0 2010
8,709,469 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 0 2010
8,871,883 Biocompatible coating for implantable medical devices 0 2010
8,500,687 Stent delivery system having a fibrous matrix covering with improved stent retention 0 2011
8,616,152 Stent coating apparatus 0 2012
8,592,036 Nanoshells on polymers 0 2012
8,758,801 Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages 0 2012
8,586,075 Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages 0 2012
8,632,841 Systems and methods for rotating and coating an implantable device 0 2013
8,808,342 Nanoshell therapy 0 2013
8,871,236 Biocompatible polyacrylate compositions for medical applications 0 2013
 
INNOVATIONAL HOLDINGS LLC (14)
7,819,912 Expandable medical device with beneficial agent delivery mechanism 0 2003
7,056,338 Therapeutic agent delivery device with controlled therapeutic agent release rates 78 2003
7,896,912 Expandable medical device with S-shaped bridging elements 0 2004
D516723 Stent wall structure 15 2004
7,517,362 Therapeutic agent delivery device with controlled therapeutic agent release rates 2 2004
D523558 Stent wall structure 16 2005
8,187,321 Expandable medical device for delivery of beneficial agent 0 2005
7,850,727 Expandable medical device for delivery of beneficial agent 3 2005
7,850,728 Expandable medical device for delivery of beneficial agent 1 2006
8,449,901 Implantable medical device with beneficial agent concentration gradient 0 2006
8,361,537 Expandable medical device with beneficial agent concentration gradient 1 2007
8,206,435 Expandable medical device for delivery of beneficial agent 1 2009
8,439,968 Expandable medical device for delivery of beneficial agent 1 2011
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BOSTON SCIENTIFIC SCIMED, INC. (10)
8,118,861 Bifurcation stent and balloon assemblies 1 2007
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7,951,191 Bifurcated stent with entire circumferential petal 0 2007
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7,833,266 Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment 0 2007
8,277,501 Bi-stable bifurcated stent petal geometry 2 2007
7,815,675 Stent with protruding branch portion for bifurcated vessels 1 2008
8,016,878 Bifurcation stent pattern 0 2009
7,951,192 Stent with protruding branch portion for bifurcated vessels 3 2009
8,425,590 Stent with protruding branch portion for bifurcated vessels 0 2011
 
ABBOTT LABORATORIES (5)
7,597,764 System of loading beneficial agent to a prosthesis by fluid-jet 4 2006
8,524,148 Method of integrating therapeutic agent into a bioerodible medical device 1 2006
8,221,495 Integration of therapeutic agent into a bioerodible medical device 3 2006
7,645,476 Method of loading beneficial agent to a prosthesis by fluid-jet application 2 2007
8,001,926 System and method of loading and detecting beneficial agent on a prosthesis 2 2009
 
WYETH (4)
7,261,735 Local drug delivery devices and methods for maintaining the drug coatings thereon 57 2001
8,303,609 Coated medical devices 0 2001
7,195,640 Coated medical devices for the treatment of vulnerable plaque 69 2002
8,182,527 Heparin barrier coating for controlled drug release 0 2004
 
CONOR MEDSYSTEMS, INC. (2)
7,208,010 Expandable medical device for delivery of beneficial agent 29 2001
7,208,011 Implantable medical device with drug filled holes 73 2002
 
SURMODICS, INC. (2)
7,550,443 Process and systems for biocompatible surfaces 2 2005
7,550,444 Composition and method for preparing biocompatible surfaces 2 2005
 
Cardiac Pacemakers, Inc. (1)
8,696,564 Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth 0 2004
 
Conor Medsystems, LLC. (1)
7,909,865 Expandable medical device for delivery of beneficial agent 2 2009
 
ORBUSNEICH MEDICAL, INC. (1)
8,088,060 Progenitor endothelial cell capturing with a drug eluting implantable medical device 0 2006
 
Other [Check patent profile for assignment information] (1)
8,888,841 Bioabsorbable implants 0 2011

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