Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

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United States of America Patent

PATENT NO 6713452
APP PUB NO 20030060606A1
SERIAL NO

09873777

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Abstract

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A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin.

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Patent Owner(s)

Patent OwnerAddress
BIOCON LIMITED20TH K M HOSUR ROAD ELECTRONIC CITY 560100

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ansari, Aslam M Rockville, MD 16 353
Ekwuribe, Nnochiri N Cary, NC 63 1265
Odenbaugh, Amy L Morrisville, NC 17 244
Price, Christopher H Chapel Hill, NC 28 507

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