US Patent No: 6,716,412
Number of patents in Portfolio can not be more than 2000
Methods of ultrasound treatment using gas or gaseous precursor-filled compositions
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Apr 6, 2004
Issued date -
Mar 21, 2001
filing date -
09/813,484
serial no -
In Force
status
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Abstract
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent | 213 | 1987 | |
| 5,409,688 Gaseous ultrasound contrast media | 164 | 1992 | |
| 5,558,855 Phase shift colloids as ultrasound contrast agents | 97 | 1993 | |
| 5,393,524 Methods for selecting and using gases as ultrasound contrast media | 159 | 1993 | |
| 5,529,766 Contrast agents | 88 | 1993 | |
| 5,536,490 Contrast agents | 97 | 1993 | |
| 5,595,723 Method for preparing storage stable colloids | 76 | 1993 | |
| 5,558,853 Phase shift colloids as ultrasound contrast agents | 136 | 1994 | |
| 5,562,893 Gas-filled microspheres with fluorine-containing shells | 82 | 1994 | |
| 5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging | 129 | 1994 | |
| 5,573,751 Persistent gaseous bubbles as ultrasound contrast media | 74 | 1994 | |
| 5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas | 99 | 1995 | |
| 5,558,094 Methods for using persistent gases as ultrasound contrast media | 92 | 1995 | |
| 5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid | 58 | 1995 | |
| 5,567,413 Flexible amphiphilic microbubbles for ultrasound | 90 | 1995 | |
| 5,676,928 Liposomes | 78 | 1995 | |
| 5,707,606 Phase shift colloids as ultrasound contrast agents | 52 | 1995 | |
| 5,707,607 Phase shift colloids as ultrasound contrast agents | 56 | 1995 | |
| 6,331,289 Targeted diagnostic/therapeutic agents having more than one different vectors | 51 | 1997 | |
| 6,261,537 Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors | 83 | 1997 | |
| 6,159,445 Light imaging contrast agents | 135 | 1997 | |
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| 5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 181 | 1990 | |
| 5,205,290 Low density microspheres and their use as contrast agents for computed tomography | 116 | 1991 | |
| 5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 151 | 1991 | |
| 5,281,408 Low density microspheres and their use as contrast agents for computed tomography | 136 | 1993 | |
| 5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents | 93 | 1993 | |
| 5,469,854 Methods of preparing gas-filled liposomes | 165 | 1993 | |
| 5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 169 | 1993 | |
| 5,456,900 Low density microspheres and their use as contrast agents for computed tomography | 65 | 1993 | |
| 5,542,935 Therapeutic delivery systems related applications | 245 | 1993 | |
| 5,585,112 Method of preparing gas and gaseous precursor-filled microspheres | 170 | 1993 | |
| 5,830,430 Cationic lipids and the use thereof | 82 | 1995 | |
| 5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications | 126 | 1995 | |
| 5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications | 85 | 1995 | |
| 5,853,752 Methods of preparing gas and gaseous precursor-filled microspheres | 79 | 1995 | |
| 5,846,517 Methods for diagnostic imaging using a renal contrast agent and a vasodilator | 88 | 1997 | |
| 6,056,938 Cationic lipids and the use thereof | 43 | 1998 | |
|
|
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| 4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport | 153 | 1986 | |
| 4,919,895 Apparatus for oxygenation of liquid state dissolved oxygen-carrying formulation | 79 | 1987 | |
| 4,987,154 Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use | 131 | 1987 | |
| 4,927,623 Dissolution of gas in a fluorocarbon liquid | 161 | 1988 | |
| 5,080,885 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport | 55 | 1989 | |
| 5,077,036 Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid | 44 | 1990 | |
| 4,993,415 Magnetic resonance imaging with perfluorocarbon hydrides | 115 | 1990 | |
| 5,393,513 Stable, highly concentrated fluoro carbon emulsions | 33 | 1993 | |
| 5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties | 90 | 1993 | |
| 5,679,459 Perfluorinated amphiphilic phosphorous compounds: liposomal compositions | 52 | 1995 | |
|
|
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| 4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles | 202 | 1988 | |
| 5,107,842 Method of ultrasound imaging of the gastrointestinal tract | 92 | 1991 | |
| 5,315,997 Method of magnetic resonance imaging using diamagnetic contrast | 130 | 1992 | |
| 5,716,597 Emulsions as contrast agents and method of use | 60 | 1993 | |
| 5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent | 118 | 1994 | |
| 5,536,489 Emulsions as contrast agents and method of use | 123 | 1995 | |
| 5,606,973 Liquid core microdroplets for ultrasound imaging | 63 | 1995 | |
| 5,732,707 Method of ultrasonically quantitating myocardial perfusion using as intravenously injected tracer | 99 | 1996 | |
| 5,855,865 Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas | 56 | 1997 | |
|
|
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| 4,276,885 Ultrasonic image enhancement | 270 | 1979 | |
| 4,265,251 Method of determining pressure within liquid containing vessel | 133 | 1979 | |
| 4,442,843 Microbubble precursors and methods for their production and use | 210 | 1981 | |
| 4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics | 265 | 1982 | |
| 4,657,756 Microbubble precursors and apparatus for their production and use | 232 | 1983 | |
| 4,681,119 Method of production and use of microbubble precursors | 197 | 1986 | |
| 4,918,065 Corticoid-containing preparation for topical application | 51 | 1988 | |
| 5,501,863 Contrast media synthesized from polyaldehydes | 112 | 1995 | |
|
|
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| 5,271,928 Stable microbubbles suspensions injectable into living organisms | 164 | 1991 | |
| 5,310,540 Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography | 122 | 1992 | |
| 5,413,774 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 132 | 1992 | |
| 5,380,519 Stable microbubbles suspensions injectable into living organisms | 149 | 1993 | |
| 5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method | 150 | 1994 | |
| 5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography | 64 | 1995 | |
| 6,258,378 Delivery of biologically active substance to target sites in the body of patients | 31 | 1999 | |
|
|
|||
| 4,192,859 Contrast media containing liposomes as carriers | 119 | 1978 | |
| 5,711,933 Method of making polymeric gas or air filled microballoons for ultrasonic echography | 89 | 1994 | |
| 5,531,980 Stable microbubbles suspensions injectable into living organisms | 93 | 1994 | |
| 5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 74 | 1995 | |
| 5,567,414 Stable microbubbles suspensions injectable into living organisms | 92 | 1995 | |
| 5,643,553 Stable microbubbles suspensions injectable into living organisms | 94 | 1995 | |
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| 5,605,673 Stabilized microbubble compositions for ultrasound | 95 | 1994 | |
| 5,540,909 Harmonic ultrasound imaging with microbubbles | 139 | 1994 | |
| 5,639,443 Stabilized microbubble compositions | 92 | 1995 | |
| 5,626,833 Ultrasound imaging method using microbubbles | 65 | 1995 | |
| 5,804,162 Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients | 50 | 1995 | |
| 5,733,527 Methods for harmonic imaging with ultrasound | 61 | 1996 | |
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| 5,498,421 Composition useful for in vivo delivery of biologics and methods employing same | 213 | 1994 | |
| 5,508,021 Non-fluorinated polymeric shells for medical imaging | 86 | 1994 | |
| 5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging | 125 | 1995 | |
| 5,512,268 Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof | 86 | 1995 | |
| 5,639,473 Methods for the preparation of nucleic acids for in vivo delivery | 83 | 1995 | |
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| 5,567,415 Ultrasound contrast agents and methods for their manufacture and use | 83 | 1994 | |
| 5,560,364 Suspended ultra-sound induced microbubble cavitation imaging | 147 | 1995 | |
| 5,648,098 Thrombolytic agents and methods of treatment for thrombosis | 39 | 1995 | |
| 5,849,727 Compositions and methods for altering the biodistribution of biological agents | 40 | 1996 | |
| 5,740,807 Suspended ultra-sound induced microbubble cavitation imaging | 50 | 1996 | |
|
|
|||
| 5,514,720 Stable emulsions of highly fluorinated organic compounds | 17 | 1988 | |
| 5,350,571 Emulsions of highly fluorinated organic compounds | 79 | 1992 | |
| 5,571,498 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). | 27 | 1994 | |
| 5,635,539 Stable emulsions of highly fluorinated organic compounds | 20 | 1996 | |
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| 4,737,323 Liposome extrusion method | 186 | 1986 | |
| 4,781,871 High-concentration liposome processing method | 119 | 1986 | |
| 4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation | 270 | 1987 | |
| 5,013,556 Liposomes with enhanced circulation time | 456 | 1989 | |
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| 4,921,706 Unilamellar lipid vesicles and method for their formation | 114 | 1984 | |
| 4,898,734 Polymer composite for controlled release or membrane formation | 185 | 1988 | |
| 4,893,624 Diffuse focus ultrasound hyperthermia system | 117 | 1988 | |
| 5,565,215 Biodegradable injectable particles for imaging | 96 | 1994 | |
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| 4,420,442 Manufacturing process for hollow microspheres | 106 | 1982 | |
| 4,421,562 Manufacturing process for hollow microspheres | 93 | 1983 | |
| 4,549,892 Process for producing hollow, bilayered silicate microspheres | 65 | 1983 | |
| 4,540,629 Hollow microspheres with organosilicon-silicate walls | 78 | 1984 | |
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| 5,785,950 Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them | 22 | 1994 | |
| 5,502,094 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use | 59 | 1995 | |
| 5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use | 70 | 1996 | |
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| 5,196,183 Contrast agents for ultrasound imaging | 111 | 1991 | |
| 5,354,549 Iodinated esters | 73 | 1991 | |
| 5,569,449 Gaseous microparticles as ultrasound contrast agents | 85 | 1995 | |
|
|
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| 4,572,203 Contact agents for ultrasonic imaging | 251 | 1983 | |
| 4,718,433 Contrast agents for ultrasonic imaging | 238 | 1985 | |
| 4,774,958 Ultrasonic imaging agent and method of preparation | 227 | 1987 | |
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|
|||
| 5,425,366 Ultrasonic contrast agents for color Doppler imaging | 220 | 1993 | |
| 6,068,857 Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production | 51 | 1996 | |
|
|
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| 4,866,096 Stable fluorochemical aqueous emulsions | 67 | 1987 | |
| 4,895,876 Concentrated stable fluorochemical aqueous emulsions containing triglycerides | 56 | 1987 | |
|
|
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| 5,958,371 Site specific binding system, nuclear imaging compositions and methods | 29 | 1997 | |
| 5,989,520 Site specific binding system, imaging compositions and methods | 24 | 1998 | |
|
|
|||
| 4,310,505 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances | 120 | 1979 | |
| 4,310,506 Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species | 133 | 1980 | |
|
|
|||
| 4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures | 174 | 1985 | |
| 5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles | 221 | 1990 | |
|
|
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| 5,558,092 Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously | 281 | 1995 | |
| 5,770,222 Therapeutic drug delivery systems | 172 | 1995 | |
|
|
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| 4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal | 113 | 1985 | |
| 5,536,753 Stable perfluorocarbon and oil emulsions | 15 | 1990 | |
|
|
|||
| 4,530,360 Method for healing bone fractures with ultrasound | 179 | 1982 | |
| 5,556,372 Apparatus for ultrasonic bone treatment | 104 | 1995 | |
|
|
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| 4,569,836 Cancer treatment by intracellular hyperthermia | 89 | 1983 | |
| 4,731,239 Method for enhancing NMR imaging; and diagnostic use | 118 | 1986 | |
|
|
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| 5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging | 75 | 1993 | |
| 5,997,898 Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery | 22 | 1995 | |
|
|
|||
| 4,620,546 Ultrasound hyperthermia apparatus | 135 | 1985 | |
| 5,485,839 Method and apparatus for ultrasonic wave medical treatment using computed tomography | 103 | 1994 | |
|
|
|||
| 5,114,703 Percutaneous lymphography using particulate fluorocarbon emulsions | 136 | 1990 | |
| 5,496,536 Percutaneous lymphography | 36 | 1995 | |
|
|
|||
| 4,728,575 Contrast agents for NMR imaging | 117 | 1985 | |
| 5,008,109 Vesicle stabilization | 75 | 1988 | |
|
|
|||
| 5,000,960 Protein coupling to lipid vesicles | 97 | 1989 | |
| 5,219,538 Gas and oxygen carrying lipid vesicles | 83 | 1991 | |
|
|
|||
| 5,213,804 Solid tumor treatment method and composition | 178 | 1991 | |
| 5,620,689 Liposomes for treatment of B-cell and T-cell disorders | 84 | 1995 | |
|
|
|||
| 4,426,330 Synthetic phospholipid compounds | 128 | 1981 | |
| 4,534,899 Synthetic phospholipid compounds | 164 | 1983 | |
|
|
|||
| 5,562,608 Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation | 166 | 1995 | |
| 5,707,352 Pulmonary delivery of therapeutic agent | 134 | 1995 | |
|
|
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| 4,544,545 Liposomes containing modified cholesterol for organ targeting | 357 | 1983 | |
| 4,900,540 Lipisomes containing gas for ultrasound detection | 179 | 1983 | |
|
|
|||
| 5,192,549 Method of amphiphatic drug loading in liposomes by pH gradient | 92 | 1989 | |
| 5,316,771 Method of amphiphatic drug loading in liposomes by ammonium ion gradient | 96 | 1992 | |
|
|
|||
| 4,790,891 Process for the production of a cartridged explosive with entrapped bubbles | 81 | 1987 | |
|
|
|||
| 4,693,999 Liposomes containing steroid esters | 59 | 1985 | |
|
|
|||
| 5,569,448 Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions | 127 | 1995 | |
|
|
|||
| 5,980,936 Multiple emulsions comprising a hydrophobic continuous phase | 22 | 1997 | |
|
|
|||
| 4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use | 105 | 1981 | |
|
|
|||
| 5,362,478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell | 132 | 1993 | |
|
|
|||
| 4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants | 85 | 1987 | |
|
|
|||
| 4,972,002 Process for producing cellular plastics by the polyisocyanate polyaddition method by means of stable emulsions containing blowing agents, and such emulsions | 82 | 1989 | |
|
|
|||
| 4,224,179 Process for the preparation of liposomes in aqueous solution | 234 | 1978 | |
|
|
|||
| 5,410,516 Ultrasonic processes and circuits for performing them | 200 | 1993 | |
|
|
|||
| 4,663,161 Liposome methods and compositions | 101 | 1985 | |
|
|
|||
| 4,675,310 Liposome composition as gas transport agents | 85 | 1985 | |
|
|
|||
| 4,603,044 Hepatocyte Directed Vesicle delivery system | 119 | 1984 | |
|
|
|||
| 4,646,756 Ultra sound hyperthermia device | 123 | 1983 | |
|
|
|||
| 4,938,947 Aerosol composition for in vivo imaging | 82 | 1988 | |
|
|
|||
| 4,933,121 Process for forming liposomes | 76 | 1988 | |
|
|
|||
| 4,342,826 Immunoassay products and methods | 107 | 1981 | |
|
|
|||
| 5,571,797 Method of inducing gene expression by ionizing radiation | 49 | 1994 | |
|
|
|||
| 4,621,023 Method of homogenizing dispersions of hydrated lipidic lamellar phases and suspensions obtained by the said method | 45 | 1983 | |
|
|
|||
| 4,315,514 Method and apparatus for selective cell destruction | 172 | 1980 | |
|
|
|||
| 4,830,858 Spray-drying method for preparing liposomes and products produced thereby | 131 | 1985 | |
|
|
|||
| 5,078,994 Microgel drug delivery system | 93 | 1990 | |
|
|
|||
| 5,008,050 Extrusion technique for producing unilamellar vesicles | 136 | 1989 | |
|
|
|||
| 4,331,654 Magnetically-localizable, biodegradable lipid microspheres | 221 | 1980 | |
|
|
|||
| 4,984,573 Method of electron spin resonance enhanced magnetic resonance imaging | 68 | 1988 | |
|
|
|||
| 5,403,575 Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them | 24 | 1991 | |
|
|
|||
| 5,171,755 Emulsions of highly fluorinated organic compounds | 113 | 1988 | |
|
|
|||
| 5,205,287 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 184 | 1992 | |
|
|
|||
| 4,776,991 Scaled-up production of liposome-encapsulated hemoglobin | 118 | 1986 | |
|
|
|||
| 5,496,535 Fluorocarbon contrast media for use with MRI and radiographic imaging | 73 | 1991 | |
|
|
|||
| 5,247,935 Magnetic resonance guided focussed ultrasound surgery | 111 | 1992 | |
|
|
|||
| 5,593,680 New cosmetic or dermopharmaceutical compositions in the form of aqueous gels modified by the addition of expanded microspheres | 69 | 1994 | |
|
|
|||
| 5,672,585 Method and composition for treating thrombosis | 53 | 1995 | |
|
|
|||
| 5,686,102 Pharmacological composition for topical administration | 75 | 1996 | |
|
|
|||
| 4,428,924 Preparation for diagnostic radiology | 65 | 1980 | |
|
|
|||
| 4,229,360 Process for the dehydration of a colloidal dispersion of lipsomes | 186 | 1978 | |
|
|
|||
| 5,194,266 Amphotericin B/cholesterol sulfate composition and method | 73 | 1991 | |
|
|
|||
| 5,198,225 Hydrated lipidic lamellar phases or liposomes based on ecdysteroids | 79 | 1991 | |
|
|
|||
| 4,834,964 Use of charged nitroxides as NMR image enhancing agents for CSF | 78 | 1986 | |
|
|
|||
| 5,362,477 19F magnetic resonance imaging agents which include a nitroxide moiety | 48 | 1992 | |
|
|
|||
| 5,612,318 Control of gene expression by ionizing radiation | 45 | 1994 | |
|
|
|||
| 4,427,649 Pharmaceutical compositions | 87 | 1981 | |
|
|
|||
| 5,147,631 Porous inorganic ultrasound contrast agents | 185 | 1991 | |
|
|
|||
| 5,612,057 Acoustically reflective liposomes and methods to make and use same | 50 | 1995 | |
|
|
|||
| 5,433,204 Method of assessing placentation | 134 | 1993 | |
|
|
|||
| 5,194,188 Process and a device for the direct production of liposomes | 16 | 1991 | |
|
|
|||
| 5,004,611 Pro-liposome compositions | 83 | 1988 | |
|
|
|||
| 4,533,254 Apparatus for forming emulsions | 246 | 1984 | |
|
|
|||
| 5,135,000 Method of measuring regional tissue blood flow | 97 | 1991 | |
|
|
|||
| 5,380,411 Ultrasound or shock wave work process and preparation for carrying out same | 109 | 1990 | |
|
|
|||
| 5,049,388 Small particle aerosol liposome and liposome-drug combinations for medical use | 163 | 1989 | |
|
|
|||
| 5,195,520 Ultrasonic manometry process in a fluid by means of microbubbles | 171 | 1991 | |
|
|
|||
| 5,840,023 Optoacoustic imaging for medical diagnosis | 157 | 1996 | |
|
|
|||
| 4,863,717 Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging | 122 | 1986 | |
|
|
|||
| 5,186,922 Use of biodegradable microspheres labeled with imaging energy constrast materials | 114 | 1990 | |
|
|
|||
| 5,470,582 Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles | 100 | 1993 | |
|
|
|||
| 4,877,561 Method of producing liposome | 86 | 1987 | |
|
|
|||
| 4,658,828 Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment | 143 | 1985 | |
|
|
|||
| 5,858,399 Acoustically reflective liposomes and methods to make and use the same | 41 | 1996 | |
|
|
|||
| 4,789,501 Glass microspheres | 156 | 1984 | |
|
|
|||
| 4,485,193 Expandable synthetic resinous thermoplastic particles, method for the preparation thereof and the application therefor | 43 | 1984 | |
|
|
|||
| 4,728,578 Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers | 85 | 1986 | |
|
|
|||
| 5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging | 126 | 1994 | |
|
|
|||
| 4,767,610 Method for detecting abnormal cell masses in animals | 37 | 1984 | |
|
|
|||
| 4,689,986 Variable frequency gas-bubble-manipulating apparatus and method | 119 | 1985 | |
|
|
|||
| 5,545,396 Magnetic resonance imaging using hyperpolarized noble gases | 123 | 1994 | |
|
|
|||
| 5,196,348 Perfluoro-crown ethers in fluorine magnetic resonance spectroscopy of biopsied tissue | 56 | 1991 | |
|
|
|||
| 5,283,255 Wavelength-specific cytotoxic agents | 65 | 1992 | |
|
|
|||
| 4,586,512 Device for localized heating of biological tissues | 155 | 1985 | |
|
|
|||
| 5,552,155 Fusogenic lipsomes and methods for making and using same | 61 | 1994 | |
|
|
|||
| 5,695,460 Enhancement of ultrasound thrombolysis | 91 | 1995 | |
|
|
|||
| 5,019,370 Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging | 99 | 1989 | |
|
|
|||
| 4,615,879 Particulate NMR contrast agents for gastrointestinal application | 133 | 1983 | |
|
|
|||
| 5,045,304 Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same | 71 | 1988 | |
|
|
|||
| 5,648,095 Preparation of microparticles | 104 | 1994 | |
|
|
|||
| 4,822,534 Method of producing microspheres | 95 | 1987 | |
| 4,996,041 Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system | 103 | 1988 | |
| 5,190,766 Method of controlling drug release by resonant sound wave | 154 | 1991 | |
| 5,315,998 Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same | 157 | 1992 | |
| 5,339,814 Process for visualizing tissue metabolism using oxygen-17 | 50 | 1992 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Oct 6, 2015 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |