Solid phase quenching systems
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United States of America Patent
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Apr 13, 2004
Issued Date -
N/A
app pub date -
Jun 11, 2002
filing date -
Sep 25, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino moiety, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a solid support including at least 1 quenching moiety attached to the solid support through covalent bonds, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the solid support and the unreacted agent from the biological matrix, where the unreacted agent is attached to the solid support through covalent bonds.
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