Superficial zone protein-binding molecules and uses thereof
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United States of America Patent
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Apr 13, 2004
Grant Date -
Jan 24, 2002
app pub date -
Feb 9, 2001
filing date -
Feb 9, 2000
priority date (Note) -
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status (Latency Note)
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Abstract
The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BIAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.
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