Vibrio Cholerae vaccine candidates and method of their constructing
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United States of America Patent
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Apr 20, 2004
Grant Date -
N/A
app pub date -
Dec 4, 2000
filing date -
Dec 30, 1997
priority date (Note) -
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Abstract
Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA mutant of Vibrio cholerae and the general methodology of making along with the sequence of thyA gene are also described.
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