Isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof

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United States of America Patent

PATENT NO 6723724
APP PUB NO 20020119983A1
SERIAL NO

09839206

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Abstract

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The present invention relates to isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D.sub.3 or D.sub.4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, ##STR1## wherein R.sub.1, R.sub.2, X and n are the same as defined in the specification.

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Patent Owner(s)

Patent OwnerAddress
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY291 DAEHAK-RO YUSEONG-GU DAEJEON 34141 34141
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY5 HWARANG-RO 14-GIL SEONGBUK-GU SEOUL 02792 02792
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY141 GAJEONG-RO YUSEONG-GU DAEJEON 34114 34114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cha, Mi Young Kyungki-do, KR 18 106
Cho, Yong Seo Seoul, KR 22 78
Choi, Kyung Il Seoul, KR 35 145
Jeong, Dae Young Daejeon, KR 8 23
Kang, Kyung Ho Jeola-bookdo, KR 11 16
Koh, Hun Yeong Kyungki-do, KR 14 85
Kong, Jae Yang Daejeon, KR 16 69
Lee, Hee-Yoon Daejeon, KR 9 19
Pae, Ae Nim Seoul, KR 48 178

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