Mu-conopeptides
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United States of America Patent
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Apr 27, 2004
Grant Date -
Mar 13, 2003
app pub date -
Jul 23, 2001
filing date -
Jul 21, 2000
priority date (Note) -
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Abstract
The present invention is to .mu.-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the .mu.-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The .mu.-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the .mu.-conopeptides and encoding propeptides, as well as the propeptides.
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