Recombinant anti-CCR2 antibodies and methods of use therefor
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United States of America Patent
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Apr 27, 2004
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app pub date -
Feb 3, 2000
filing date -
Jul 23, 1998
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Abstract
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
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