Parvovirus vaccine as viral coat protein fusions
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United States of America Patent
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May 4, 2004
Grant Date -
N/A
app pub date -
Mar 8, 2000
filing date -
Mar 8, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusion proteins of the invention have are useful as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, or for use as vaccine antigens for the induction of protective immunity against the parvovirus. Feline parvovirus epitopes were fused to the N-terminus of the TMV coat protein, expressed in Nicotiana plants, extracted, purified, characterized and administered to animals, resulting in protective immunity.
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